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The Anticentromere antibody test, also known as the ACA test, is performed to detect if the specific antibodies, called anticentromere antibodies, are present in the blood. These antibodies target proteins located in the centromeres, which are regions of chromosomes involved in cell division. The test helps diagnose and evaluate certain autoimmune disorders and diagnose a form of scleroderma.
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The Anticentromere antibody test, also known as the ACA test, is performed to detect if the specific antibodies, called anticentromere antibodies, are present in the blood. These antibodies target proteins located in the centromeres, which are regions of chromosomes involved in cell division. The test helps diagnose and evaluate certain autoimmune disorders and diagnose a form of scleroderma.
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What does a high anticentromere antibody level indicate?
A high level of anticentromere antibodies in the blood usually suggests the existence of systemic sclerosis (SSc), commonly known as scleroderma. Anticentromere antibodies are autoantibodies that specifically target the centromere proteins found in cell chromosomes. Their existence indicates an immune response that mistakenly targets and kills healthy cells, including those in connective tissues and blood vessels. Sources: Mayo Clinic. Anticentromere Antibody Test. Mayo Clinic Laboratories. https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/9276 National Organization for Rare Disorders (NORD). Anticentromere Antibody. https://rarediseases.org/rare-diseases/limited-cutaneous-systemic-sclerosis/