Among the rarer genetic conditions is Wolfram syndrome. It is a serious and progressive condition. As it worsens, it impairs normal body function, which can finally lead to premature death. The most distinctive feature of this condition is elevated blood sugar, which occurs due to a lack of the hormone insulin. This leads to several other problems, among which is vision loss. This condition is called optic atrophy and is among the associated conditions linked to Wolfram syndrome. Although the Wolfram syndrome prognosis is poor, you can do a lot of things to manage the symptoms of this disease.
In fact, Wolfram Syndrome is so rare that not all doctors may diagnose it right away. This is mainly because Wolfram syndrome is a neurological and progressive illness that usually starts in childhood . Diagnosis is usually made during childhood based on certain health markers. As such, it is easy to miss, which is why it is important to know all you can about the condition. This can help when you visit a doctor and arm you with the right information; here’s everything to know about the Wolfram syndrome symptoms, causes, and treatment.
Wolfram syndrome is also known as DIDMOAD, which is an acronym for ‘Diabetes Insipidus Diabetes Mellitus Optic Atrophy and Deafness. These are all the core symptoms associated with this disease. Here is a quick breakdown.
Keep in mind that type 1 and type 2 diabetes, i.e., insipidus and Mellitus, do not have the same cause. Most people with diabetes mellitus do not have insipidus. In the case of Wolfram syndrome, you can eventually develop both diabetes insipidus and Mellitus. The first condition to develop is most likely diabetes mellitus, which, if left unchecked, can cause the affected to slip into a coma .
In addition, Wolfram syndrome may cause other conditions like:
Wolfram syndrome is largely caused by gene mutations. In most cases, Wolfram syndrome is passed on from a mother or father who has this syndrome. Here, the WFS1 or WFS2 gene mutations are inherited, giving rise to the genetic disorder. In some cases, children may inherit one normal gene and one mutated gene. Here, the child will be a carrier and may not show symptoms of Wolfram syndrome. Doctors can diagnose the likelihood and confirm the diagnosis with genetic testing.
Wolfram syndrome is a progressive disease, and treatment usually is limited to the management of symptoms. There is no cure for it, but supportive treatment options can help patients lead better life. Examples of such treatments for Wolfram syndrome are:
Other symptoms also can be managed with medications and lifestyle changes. In the future, gene therapy may be an option to treat this disease, and research is underway.
Additional Read: 10 Important Diabetes Tests for a Healthy Life
Wolfram syndrome is a rare condition which can be fatal if left untreated. With all this important information regarding this disease, you can make the right choice if you or anyone close to you is diagnosed with this condition. You can also book online consultation on Bajaj Finserv Health to learn how to manage the symptoms of this disease. You can further avail guidance on associated health conditions such as diabetes and hypertension by talking to doctors on the platform and leading a healthier life.
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